Role of interleukin-5 in allergic fungal sinusitis: deeper insight

Abstract Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is an allergic response characterized by type 2 inflammatory reactions mediated T helper cells (Th2). Th2 elevated cytokines related to the humoral response, including Interleukin-4 (IL-4), IL-5, IL-6, IL-9, IL-10, IL-13, IL-25 and IL-33. Allergic fungal sinusitis (AFS) a distinguishable form of CRSwNP primary localized disease non-invasive hyphae, which causes immunoglobulin E (IgE)-mediated mucosal hypersensitivity resulting in formation eosinophilic mucin. Interleukin-5 (IL-5) pro-inflammatory factor that plays very important role eosinophil biology. Objective To explore relation between IL-5 tissue protein expression AFS. Methods A prospective study performed on 70 patients divided into groups (50 cases AFS 20 control who underwent septoplasty partial inferior turbinectomy) assess IL5 compared control. Results was overexpressed group denoting as inflammation highlighting positive correlation Lund MacKay radiological score Sino-nasal Outcome Test (SNOT-22) for severity chronic (CRS) symptoms. Conclusion pivotal pathogenesis Thus, our results provide encouraging evidence supporting targeting eligible therapy promising benefits